If you’re a dog parent, you’ve probably had that moment: the day your energetic companion suddenly seems a little slower, a little quieter, or a little less eager to chase the ball they once lived for. Ageing creeps up on dogs quickly, especially larger breeds, and many owners end up asking the same hopeful question: Is there a way to help my dog stay healthier for longer?That’s the idea behind Loyal’s longevity research, which focuses on slowing the ageing process in senior dogs by targeting the biological factors that accelerate ageing. The science may sound complex, but the goal is simple: extend your dog’s healthy, active years; not just add time, but improve the quality of it.
Why scientists are testing an ageing-slowing pill for dogs
Loyal’s research highlights a key insight: large and giant-breed dogs age more quickly because of how their bodies grow. Early in life, these dogs produce higher levels of growth-linked hormones, and one of the major players is IGF-1 (Insulin-Like Growth Factor 1). This hormone is important for puppyhood growth but can contribute to faster ageing later on.Small dogs naturally have lower IGF-1 levels, which partly explains why they tend to live longer.Loyal’s longevity drug is built on this biological difference. According to their findings, the treatment aims to:
- Reduce excess IGF-1 activity in older dogs
- Slow biological ageing at the cellular and metabolic levels
- Support heart and organ function that tends to decline with age
- Promote healthier weight and mobility in senior dogs
In simple terms, it’s designed to help a dog’s body behave more like that of a naturally long-lived small breed, potentially slowing the processes that accelerate ageing in larger dogs.This is not a “stop ageing forever” pill, and it’s not meant to turn back the clock, but it may help dogs age more gracefully, comfortably, and slowly.Their investigational drug, known as LOY-002, is projected for potential FDA review in 2026, although FDA approval is not guaranteed. Loyal is collecting supporting evidence through the STAY study, a large-scale, placebo-controlled clinical trial observing real-world outcomes in senior dogs.
Common signs of ageing in dogs you shouldn’t ignore
Dogs don’t always show their discomfort clearly. Sometimes ageing looks subtle, and by the time pet parents notice changes, the dog has already entered seniorhood. If you’re wondering whether your dog is showing early signs, here’s what vets commonly associate with canine ageing.Physical signs of ageing
- Reduced stamina on walks
- Trouble getting up from rest
- Difficulty climbing stairs or jumping onto furniture
- Noticeable muscle loss
- Stiffness, especially in cold weather
- Greying around the muzzle, eyes, or paws
Behavioural signs of ageing
- Sleeping more than usual
- Reduced excitement or slower response to stimuli
- Seeming confused or “lost” in familiar environments
- Forgetting routines or commands they previously knew
- Increased anxiety or restlessness, especially at night
Health-related signs of ageing
- Weight gain or unexplained weight loss
- Loss of appetite or changes in eating habits
- Heart-related concerns (very common in large breeds)
- Joint pain or arthritis
- Vision or hearing decline
- Slower healing from minor injuries
Recognising these signs early gives you more options to support your dog, including lifestyle adjustments, vet care, and potentially longevity-focused treatments like the ones Loyal is studying.
How a longevity drug may help your senior dog stay healthier
Loyal’s research suggests that by targeting IGF-1 and slowing internal ageing markers, dogs may experience improvements that show up in everyday life.Here’s how such a drug may support your ageing dog:
- Better mobility and comfort
By slowing processes that accelerate joint and muscle decline, older dogs may stay active longer.Larger dogs are prone to heart issues; a treatment that supports cardiovascular ageing could help them stay energetic.Ageing affects weight control. A steadier metabolism can reduce sudden weight changes.
- Sharper alertness and engagement
Slower cellular ageing can translate to improved cognitive function, meaning brighter eyes, quicker responses, and more interest in activities.
- More “good days” overall
Instead of short bursts of energy followed by long periods of fatigue, dogs may enjoy more consistent daily comfort.While results will vary by individual dog, the goal, as implied in Loyal’s findings, is to increase healthspan, the portion of life spent active, comfortable, and engaged, rather than just lifespan.
Possible side effects of longevity treatments in dogs
Even the most promising treatments come with potential side effects. Loyal’s research notes that most reactions tend to be mild, but pet parents should still be aware.Potential mild side effects
- Brief fatigue or low energy
- Mild digestive upset
- Temporary decrease in appetite
- Soreness or sensitivity at the injection site
- Increased thirst or urination
Rare or more serious side effects
- Allergic reactions
- Persistent vomiting or diarrhoea
- Noticeable behavioural changes
- Swelling that doesn’t go down
- Significant pain or discomfort
As with any treatment, veterinarians recommend monitoring your dog after every dose and reporting anything unusual immediately.
Should you consider this longevity drug for your senior dog?
If your dog is entering their older years, especially if they’re a large or giant breed, then exploring longevity-focused treatment options may be worthwhile. Loyal’s research points to real potential in slowing biological ageing and supporting healthier senior years.At the end of the day, every dog owner wants the same thing: more time and more good time with the dogs they love.Disclaimer: This article is for informational purposes only and is not a substitute for professional veterinary advice, diagnosis, or treatment.Also Read | Why you should keep your cat away from lilies; know health risks
